Prospective, Longitudinal Study to Evaluate the Clinical Utility of a Predictive Algorithm to Detect Opioid Use Disorder in Chronic Pain Patients

A prospective, longitudinal study was conducted to determine the clinical utility of an algorithm-based precision medicine profile designed to assess risk associated with opioid use disorder in 5,315 patients in a clinical setting. Specifically, we sought to assess how physicians were using the profile and how its use affected patient outcomes. Ninety percent of all clinicians surveyed reported some benefit to their patient care, with the most utilization for changing the prescribed opioid and the most significant benefits from discontinuing opioids. Patients who received profile-guided care reported on average a 42% reduction in pain, and almost 40% of patients had >50% reduction in pain.